EFFECTS OF DEXMEDETOMIDINE ON HEMODYNAMICS, STRESS RESPONSE, LUNG COMPLIANCE, AND OXYGENATION INDEX IN LAPAROSCOPIC PATIENTS WITH CERVICAL CANCER

Bin Hu, Wenwen Luo, Manhe Zhang, Xin Zhao, Li Yang, Ying Wang^*

Department of Anesthesiology, Tangshan Gongren Hospital, Tangshan, 063000, China

Objective: This study aimed at exploring the effects of dexmedetomidine on hemodynamics, stress response, lung compliance, and oxygenation index (OI) in patients with cervical cancer undergoing laparoscopy. 

Methods: 86 cases of cervical cancer patients treated in our hospital from May 2019 to March 2020 were randomly divided into study and control groups according to the random number table method, 43 cases in each group. Both groups were treated with total laparoscopic hysterectomy or double adnexectomy. The study group was given dexmedetomidine intravenous infusion, while the control group was given 0.9% sodium chloride injection at the same speed. The clinical data of the two groups were compared. Hemodynamic indexes were measured before anesthesia, 5 min after intubation, 30 min after establishing pneumoperitoneum, 5 min after extubation, and 2 h after the operation. The changes in stress reaction factors before anesthesia, 5 minutes after intubation, and 30 minutes after pneumoperitoneum establishment were compared between the two groups. The changes in peak airway pressure, lung compliance, and oi were measured at 5 min after intubation, 30 min after establishing pneumoperitoneum, and 5 min after extubation. 

Results: There was no significant difference in HR, DBP, and SBP between the two groups before anesthesia and 2 hours after the operation (P>0.05); at 5 minutes after intubation, 30 minutes after establishing pneumoperitoneum, and 5 minutes after extubation, the above indexes in the study group were significantly lower than those in the control group (P<0.05). There was no significant difference in Na, cor, ACTH, and Ang Ⅱ between the two groups before anesthesia (P>0.05); the above indexes in the study group were significantly lower than those in the control group at 5 minutes after intubation and 30 minutes after the establishment of pneumoperitoneum (P<0.05). Compared with 5min after intubation, peak airway pressure and lung compliance were significantly increased, OI was significantly decreased at 30min after pneumoperitoneum establishment (P<0.05). Compared with 30min after pneumoperitoneum, peak airway pressure and lung compliance were significantly decreased; OI was significantly increased (P<0.05). 

Conclusion: Dexmedetomidine can maintain hemodynamic stability, reduce stress response, and improve lung compliance and oxygenation function of patients with cervical cancer under laparoscopy, which can play a certain role in lung protection.