CORRELATION OF PLASMA ADIPONECTIN AND AΒ DEPOSITION-RELATED INDEXES WITH VEGF, FOL, AND VITB12 IN PATIENTS WITH ALZHEIMER'S DISEASE

Hui Chen, Jinfeng He^* 

Department of Neurology in Taizhou Municipal Hospital, Taizhou 318000, PR China

Objective: This study investigates the correlation between plasma adiponectin and β-amyloid deposition-related indexes and the vascular endothelial growth factor, folic acid and vitamin B12 in patients with Alzheimer's disease (AD). 

Methods: Sixty (60) patients with AD admitted to the hospital from July 2018 to July 2019 were recruited as the study group and divided into mild (n=21), moderate (n=20) and severe (n=19) groups. Also, 30 healthy people who received examinations at the hospital during the same period were randomly enrolled in the control group. The serum adiponectin (APN), β-amyloid (Aβ) 1-40, Aβ1-42, vascular endothelial growth factor (VEGF), folic acid (FOL) and B12 (VitB12) levels of patients in each group were detected through an enzyme-linked immunosorbent assay. The serum levels of each group were compared and the correlations of serum APN, Aβ1-40 and Aβ1-42 and FOL, VEGF and VitB12 in AD patients were studied. 

Results: The serum Aβ1-40 and Aβ1-42 levels of AD patients in the mild group were significantly higher than those in the control group. The Aβ1-40 and Aβ1-42 levels of AD patients in the mild group were significantly higher than those in the mild group and the control group, as well as those in the mild to moderate group and the control group, and the differences were statistically significant (P<0.01). The level of serum APN in patients with mild AD was significantly lower than that in the control group. The level of APN in patients with AD in the mild group was significantly lower than that in the mild group and the control group, and the differences were statistically significant (P<0.01). The levels of serum FOL, VEGF and VitB12 in patients with mild AD were significantly lower than those in the control group. The levels of FOL, VEGF and VitB12 in patients with AD in the mild group were significantly lower than those in the mild group and the control group. The levels of FOL, VEGF and VitB12 in patients with severe AD were significantly lower than those in the mild to moderate group and the control group, and the differences were statistically significant (P<0.01). Regarding the correlations with FOL, VEGF and VitB12, APN was positively correlated (r were 0.361, 0.426 and 0.436, P<0.05), Aβ1-40 was negatively correlated (r were -0.261, -0.124 and -0.412, P<0.05) and Aβ1-42 was also negatively correlated (r were -0.325, -0.479 and -0.384, P<0.05). 

Conclusion: The level of APN in AD patients is decreased and positively correlated with FOL, VEGF and VitB12, and the levels of β-amyloid deposition-related indexes are increased and negatively correlated with FOL, VEGF and VitB12. The changes of APN and β-amyloid deposition-related indexes in AD patients may be related to the structure and functional damage of blood vessels.