VITAMIN D LEVELS IN WOMEN WITH FIBROMYALGIA AND RELATIONSHIP BETWEEN PAIN, TENDER POINT COUNT AND DISEASE ACTIVITY

RAMAZANAZIM OKYAY¹ , BURHANFATIH KOÇYIĞIT² , SAVAŞ GÜRSOY²

¹ Ceyhan Community Health Center, Adana, Turkey, ² Gaziantep University Medical Faculty, Department of Physical Medicine and Rehabilitation, Gaziantep, Turkey

Introduction: Fibromyalgia syndrome (FMS) is a chronic syndrome characterized by widespread musculoskeletal pain, tender points and fatigue. There are several studies suggesting a possible relationship between musculoskeletal pain and vitamin D deficiency. In this study, we aimed to compare serum vitamin D levels between fibromyalgia patients and control groups and investigate the relationship between vitamin D and clinical findings on patients with fibromyalgia syndrome.

Materials and methods: This case control study enrolled 79 women with fibromyalgia who fulfilled the American College of Rheumatology 1990 criteria and 80 healthy women. All subjects were evaluated with vitamin D and other biochemical markers. The patients were divided into three groups based on their serum vitamin D levels (normal, insufficient, deficient). Visual analogue scale and fibromyalgia impact questionnaire were used to evaluate the patients with FMS.

Results: Mean serum vitamin D levels were lower in the FMS group than in the controls (12.99±8.37 ng/ml vs.16.05±9.42 ng/ml, p=0.037). Vitamin D level was significantly negative correlated with visual analogue scale, tender point count and fibromyalgia impact questionnaire ( p=0.000, r=-0.578; p=0.001, r=-0.361; p=0.000, r=-0.621).

Conclusion: It was concluded that vitamin D deficiency may be related to the clinical findings in patients with FMS.