LIPING SUN1, SHIXUAN WANG2, ZHENG DONG2, XINZHOU ZHANG1
1Department of Nephrology, Shenzhen People's Hospital, Second Clinical Medical College, Jinan University, Shenzhen 518020, China - 2Department of Cellular Biology & Anatomy, Medical College of Georgia at Augusta University and Charlie Norwood VA Medical Center, Augusta, GA 30912, USA
Mechanistic target of rapamycin (mTOR) protein is a conserved serine/threonine kinase that is essential in many signaling pathways. It forms, with different protein components, two distinct protein complexes, mTOR complex 1 and 2. mTOR signaling has been studied under physiological and pathological conditions of the kidney, such as kidney injury/repair and polycystic kidney dis- ease (PKD). mTOR inhibition with rapamycin has been reported to affect the disease progress and be beneficial in animal models. Here, we briefly overview recent advances of mTOR signaling pathway in studying kidney injury/repair and PKD, and try to eluci- date further studies.
mTOR, AKI, PKD, regulator