ZHANG LAIGEN1, ZHANG YAN2, WANG PEIMIN1
1Department of Orthopedics and Traumatology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029 - 2School of public administration, Nanjing Normal University, Nanjing, 210029
Objective: To investigate the effect of combination of Yanyu tongluo plaster and celecoxib capsule on treating knee osteoarthri- tis, and its impact on serum and knee joint fluid levels of irisin and SDF-1.
Methods: Knee osteoarthritis patients (numbering 400) admitted to the Department of Orthopaedics and Traumatology, Affiliated Hospital of Nanjing University from January 2013 to January 2016 were recruited into the study. They were randomly assigned to either control group or observation group (200/group). All patients received celecoxib, but those in the observation group were given Yanyu tongluo plaster. Treatment effectiveness, improvement of specific clinical manifestations, and levels of knee joint fluid SDF-1 and serum irisin were assayed in the two groups using enzyme-linked immunosorbent assay (ELISA).
Results: Total clinical effectiveness in the observation group (91.5%) was much higher than that of the control group (75.5%, p < 0.05). There were no significant differences in Lysholm scores and VAS scores between the two groups before treatment (p > 0.05). However, after treatment, the Lysholm scores of two groups increased significantly, but values in the observation group were signifi- cantly higher than corresponding values in the control group (p < 0.05). Moreover, the VAS scores of two groups decreased signifi- cantly, but VAS scores in the observation group was much less than VAS scores in the control group (p < 0.05). No significant differ- ences existed serum SDF-1 and irisin or knee joint fluid between the two groups before treatment. After treatment, serum SDF-1 and knee joint fluid in the two groups decreased significantly, but these parameters were significantly lower in the observation group than in the control group (p < 0.05). Similarly, serum irisin and knee joint fluid of two groups were significantly increased after treatment, but their levels in the observation group were much higher than those in the control group (p < 0.05).
Conclusion: The combination of Yanyu tongluo plaster and celecoxib may play a positive role in treating knee osteoarthritis through regulation of serum SDF-1 and irisin or knee joint fluid. This finding merits further exploration with a view to adopting them for clinical application.
Yanyu tongluo plaster, Celecoxib capsule, Knee osteoarthritis, SDF-1, Irisin