Authors

JIANG KUN1, 2, WANG CHAO1, 2, YAN SILEI1, 2

Departments

1Shanghai Children’s Hospital - 2Department of respiratory medicine, Affiliated Children’s Hospital of Shanghai Jiao Tong University

Abstract

Objectives: To investigate the curative effect of treatment with combination of methylprednisolone and azithromycin on pedi- atric mycoplasmal pneumonia and its effect on procalcitonin (PCT), high sensitivity C-reactive protein (hs-CRP), cardiac troponin and IL-2.

Methods: A total of 100 cases of children diagnosed with mycoplasma pneumonia and treated in our hospital from March 2014 to March 2017 were randomly divided into control group and observation group (50 cases in each group). The control group was treated with azithromycin, while the observation group was treated with methylprednisolone combined with azithromycin. Hospital stays, treatment time, clinical symptoms, symptom disappearance time, incidence of adverse reactions, and effect of clinical treatment in the two groups were analyzed statistically. At the same time, the concentrations of PCT, hs-CRP, cardiac troponin and IL-2 in serum of the two groups were determined and analyzed before and after treatment, using magnetic particle chemiluminescence (quantitative).

Results: The total treatment effectiveness in the observation group was 96%, which was significantly higher than 84% in the control group (p < 0.05). Fever cessation time, disappearance time of cough and hales, hospital stays and healing time in the obser- vation group were all significantly shorter than those in the control group (p < 0.05). The incidence of nausea, vomiting, abdominal pain, diarrhea, rash, injection site pain and liver function impairment in the observation group were lower than those in the control group (p < 0.05). The levels of PCT, hs-CRP, cardiac troponin in both groups decreased after treatment, while the IL-2 increased. There was a significant difference between values before and after treatment (p < 0.05). The degrees of changes jn PCT, hs-CRP, car- diac troponin and IL-2 in the observation group before and after treatment were significantly higher than those in the control group. After treatment, the concentrations of PCT, hs-CRP and cardiac troponin in the observation group were lower than those in the con- trol group, and the concentration of IL-2 in the observation group was higher than that in the control group (p < 0.05).

Conclusion: Compared with azithromycin, combination of methylprednisolone and azithromycin in the treatment of children with mycoplasma pneumoniae has better clinical efficiency and safety, lower inflammation and better immune balance.

Keywords

Pediatric mycoplasma pneumonia, Methylprednisolone, Azithromycin

DOI:

10.19193/0393-6384_2018_3_123