Danfeng Xu1, Yan Zhang2, Haixin Guo1, Shunlan Liu1, Zhirong Xu1, Wanhong Xu1, *
1Department of Ultrasound,the Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, Fujian, PR China - 2Department of Ophthalmology, the Second Affiliated Hospital of Fujian Medical University
Objective: to systematically evaluate the feasibility of sentinel lymph node biopsy (SLN) in patients with lymph node positive breast cancer after neoadjuvant chemotherapy (NAC).
Methods: the full-text databases of PubMed, Cochrane Library, Springer, Elsevier, national technical, Wanfang and other journals were searched by computer. The literatures of sentinel lymph node biopsy in breast cancer patients after neoadjuvant chemotherapy were included. The retrieval time was from January 2000 to December 2013. The literatures that met the inclusion criteria were analyzed by meta analysis.
Results: totally 10 clinical studies were included and 1437 patients were included. The sensitivity of sentinel lymph node biopsy was 0.867 (95% confidence interval: 0.835-0.894), and the specificity was 1.000 (95% confidence interval: 0.988-1.000).
Conclusion: sentinel lymph node biopsy after neoadjuvant chemotherapy for breast cancer patients with positive axillary lymph nodes has high sensitivity, specificity, feasibility and accuracy.
Sentinel lymph node biopsy, neoadjuvant chemotherapy, breast cancer, meta analysis.
10.19193/0393-6384_2021_1_109