Authors

Yang Shen*, Chengjun Xue*, Guoli You1, Cui Liu*, Liya Song**, #

Departments

*Department of Gastroenterology, Jian Hu Hospital Affiliated of Nan Tong University, Yancheng, PR China - **Department of Gastroenterology, Qingdao Third People's Hospital, Qingdao, PR China

Abstract

Objective: The objective is to explore the value of serum gastric cancer 7 antigen (MG7-Ag), precursor microRNA-30c (miR-30c), and gastrin 17 (G-17) in the early diagnosis of gastric cancer.

Methods: From July 2017 to May 2018, 98 patients with gastric cancer who were treated in our hospital were selected as the observation group, and 40 healthy control sera were collected from the outpatients of our hospital. The levels of G-17, miR-30c, and MG7-Ag were detected using ELISA in the two groups, and the levels of G-17, precursor RNA-30c, and MG7-Ag were measured to evaluate their value in the early diagnosis of gastric cancer.

Results: Compared with the control group, the levels of G-17 and MG7-Ag in the observation group were significantly higher, and the levels of microRNA-30c were significantly lower. There was a significant difference between the two groups (P<0.05). Compared with patients with early gastric cancer, the levels of G-17 and MG7-Ag in patients with advanced gastric cancer were significantly higher, and the levels of microRNA-30c were significantly lower. There was a significant difference between the two groups (P<0.05). Serum G-17, miR-30c, and MG7-Ag were detected in patients with gastric cancer. The areas under the receiver operating characteristic curve were 0.668, 0.921, and 0.693, respectively. The sensitivity and specificity of serum G-17 for gastric cancer patients were 60.42% and 70.70%. The sensitivity and specificity of serum miR-30c for gastric cancer patients were 90.11% and 84.23%. The sensitivity and specificity of serum MG7-Ag for gastric cancer patients were 73.11% and 76.21%.

Conclusion: Serum G-17, miR-30c, and MG7-Ag have certain clinical value in early diagnosis of gastric cancer and can be used as potential markers for early serum diagnosis of gastric cancer.

Keywords

Gastric cancer-associated antigen, miR-30c, gastrin 17, gastric cancer.

DOI:

10.19193/0393-6384_2020_3_216