Authors

Weixuan Xie*, Zhencheng Zhu*, Kunlun Luo**, #

Departments

*Wuxi Clinical School of Anhui Medical University, Wuxi, PR China - **Department of Hepatobiliary Surgery, The 904th Hospital of Joint Logistic Support Force of PLA, Wuxi, PR China

Abstract

Objective: To study the value of serum sulfhydrylase 1 (QSOX1), Golgi glycoprotein 73 (GP73) and alpha-fetoprotein (AFP) alone or in combination in the diagnosis of primary liver cancer. 

Methods: 60 patients with primary liver cancer who were treated in our hospital from July 2018 to July 2019 were selected as the liver cancer group and 40 patients with chronic hepatitis were the hepatitis group. In the same period, 30 cases of physical examination in our hospital were selected as the control group. Serum QSOX1, GP73 and AFP levels were measured and compared in each group, and the value of QSOX1, GP73 and AFP in the diagnosis of primary liver cancer was studied. 

Results: The levels of serum QSOX1, GP73 and AFP in the liver cancer group were much higher than those in the hepatitis group and the control group. The serum levels in the hepatitis group were higher than those in the control group, and the difference was statistically significant (P<0.05). The positive rates of serum QSOX1, GP73 and AFP in patients with liver cancer were 75.00%, 71.67%, and 50.00%, respectively, which were higher than those in the hepatitis group and the control group. The difference was statistically significant (P<0.05). The detection rate of AFP in the hepatitis group was 5.00%, which was higher than that of the control group. The difference was statistically significant (P<0.05). The positive rates of serum QSOX1 and GP73 in the hepatitis group were not significantly different from those in the control group (P>0.05). The receiver operating characteristic (ROC) curve analysis showed that the area under the curve (AUC) of serum QSOX1, GP73 and AFP for the diagnosis of primary liver cancer were 0.856, 0.892 and 0.802, respectively. The sensitivity was 76.58%, 88.31% and 72.52%, respectively. The specificity was 83.41%, 76.52% and 81.26%, respectively. Among them, the value of serum GP73 alone in the diagnosis of primary liver cancer was the highest, the difference was statistically significant (P<0.05). ROC curve analysis showed that the AUC of serum QSOX1+GP73, GP73+AFP, AFP+QSOX1 and QSOX1+GP73+AFP for the diagnosis of primary liver cancer were 0.911, 0.894, 0.869 and 0.919, respectively, and the sensitivity was 89.12%, 84.36%, 81.36% and 90.11%, respectively. The specificities were 76.15%, 78.59%, 79.58%, and 77.39%, respectively. Among them, serum QSOX-1+GP73+AFP had the highest value in the diagnosis of primary liver cancer, and the difference was statistically significant (P<0.05). 

Conclusion: QSOX1, GP73 and AFP have certain value in the diagnosis of primary liver cancer alone or in combination. The combination of the three of them had the highest value in the diagnosis of primary liver cancer and can be widely used in clinical settings.

Keywords

QSOX1, GP73, AFP, combined diagnosis, primary liver cancer.

DOI:

10.19193/0393-6384_2020_3_236