Authors

Lijun Zou, Qisheng Wang#

Departments

Department of Emergency, Hanchuan hospital, Hanchuan People's Hospital/Wuhan University people's Hospital, Hanchuan, PR China

Abstract

Objective: To analyse the value of miR-155 and neutrophil to lymphocyte ratio (NLR) in the prognosis of acute ischaemic stroke (AIS). 

Methods: One hundred twenty-eight patients with acute ischaemic stroke admitted to our hospital from January 2016 to January 2018 were enrolled and divided into a good prognosis group (81 cases) and a poor prognosis group (47 cases) according to the prognosis score. The levels of miR-155 and NLR in the two groups were compared. The influencing factors of poor prognosis in patients with AIS were analysed by way of multivariate logistic regression. The values of miR-155 and NLR in the prognosis were studied with the ROC curve. 

Results: The recurrence rate of cerebral infarction and the NIHSS score of admission in the poor prognosis group were significantly higher than those in the good prognosis group, and the difference was statistically significant (P<0.05). The levels of miR-155 and NLR in patients with poor prognosis were significantly higher than in those with good prognosis, and the difference was statistically significant (P<0.05). Age, miR-155, NLR, admission NIHSS score and whether recurrent cerebral infarction or not were included in multivariate logistic regression analysis. The result showed that age, miR-155, NLR and admission NIHSS scores were influential factors for poor prognosis in patients with AIS (P<0.05). ROC curve analysis indicated that the area under the curve of prognosis of patients with AIS by miR-155 and NLR was 0.825 and 0.792, respectively, the sensitivity was 85.2% and 76.2%, respectively, and the specificity was 76.5% and 75.3%, respectively, which could be specific indicators of AIS patient prognosis. 

Conclusion: The levels of miR-155 and NLR are highly expressed in patients with acute ischaemic stroke and have a certain reference value for evaluating the poor prognosis.

Keywords

miR-155, neutrophil to lymphocyte ratio, acute ischaemic stroke, prognosis.

DOI:

10.19193/0393-6384_2020_3_279