Authors

Yi Jiang, Fangqing Liu, Qiuju Li, Wenlei Wang, Xujuan Zhuang, Yanfang Yang#

Departments

Department of neurology, Cheng yang district people’s hospital, Qingdao, PR China

Abstract

Objective: To analyse the correlation of serum cystatin C (Cys-C), hyperhomocysteine (HCY) and intracranial vascular atherosclerotic stenosis in patients with acute ischaemic stroke. 

Methods: One hundred and twenty patients with acute ischaemic stroke confirmed via CT or magnetic resonance in our hospital from July 2017 to January 2019 were selected as the study subjects. According to magnetic resonance angiography (MRA), the patients were divided into three groups, namely a non-stenosis group (37 cases), a mild group (28 cases), a moderate group (21 cases) and a severe group (34 cases). There were 35 cases without lesions, 25 cases with one lesion, 15 cases with two lesions and 45 cases with multiple lesions. The levels of serum Cys-C were measured using an automatic biochemical analyser, the levels of serum Cys-C were detected via immunoturbidimetry, the levels of HCY were detected by circulating enzyme, and the correlation of serum Cys-C, HCY, the degree of vascular stenosis and the number of lesion branches was analysed using the Spearman correlation. 

Results: The age, drinking history, hypertension and diabetes history of patients with mild, moderate and severe stenosis were higher than were those of patients without stenosis (P<0.05). The levels of serum Cys-C and HCY in patients with mild, moderate and severe stenosis were higher than were those in patients without stenosis (P<0.01). The levels of HCY in patients with severe stenosis were significantly higher than were those in patients with mild stenosis (P<0.05). The level of serum Cys-C in patients with multiple vessel lesions was significantly higher than it was in patients without lesions, with one or two vessel lesions (P<0.01). The level of HCY in patients with two vessel lesions or with multiple vessel lesions was significantly higher than it was in patients without lesions (P < 0.01). Serum Cys-C and HCY levels were correlated positively with the degree of vascular stenosis and the number of lesion branches (P<0.01). 

Conclusion: Serum Cys-C and HCY levels are correlated positively with intracranial vascular atherosclerotic stenosis in patients with acute ischaemic stroke. The level of the two indicators can reflect the severity of intracranial vascular lesions. Early monitoring of serum Cys-C and HCY levels can reduce the impact on vascular atherosclerotic lesions. 

Keywords

Serum cystatin C, hyperhomocysteine, acute ischaemic stroke, atherosclerotic stenosis, correlation.

DOI:

10.19193/0393-6384_2020_3_311