Authors

Bin Di#, Xiangdong Xu, Xia Chen

Departments

Department of Cardiology, Jiading District Central Hospital Affiliated Shanghai University of Medical and Health Sciences, Shanghai, PR China

Abstract

Objective: To analyse the correlation of cytokines interleukin-10 (IL-10) and interleukin-17 (IL-17) with blood pressure and immune level in patients with essential hypertension.

Methods: From September 2017 to February 2019, 81 patients with essential hypertension were randomly selected as the study group, and 81 healthy people who underwent physical examinations in our hospital at the same time were selected as the control group. The 24-hour mean diastolic blood pressure, 24-hour mean systolic blood pressure, levels of cytokines IL-10 and IL-17 and changes of immune function indexes (immunoglobulin G [IgG], CD4+, CD8+, CD4+/ CD8+) were observed in all subjects. A Pearson correlation test was used to analyse the correlation between cytokines IL-10, IL-17 and blood pressure and immune levels in patients with essential hypertension.

Result: Compared with the control group, the average diastolic blood pressure and systolic blood pressure in the study group increased significantly after 24 hours (P<05). The level of cytokine IL-10 in the study group was significantly lower than that in the control group, and the level of IL-17 was significantly higher than that in the control group (P<.05). Compared with the control group, the levels of IgG and CD8+ in the study group increased significantly, while the levels of CD4+ and CD4+/CD8+ decreased significantly (P<.05). The Pearson correlation test showed that the IL-10 level was negatively correlated with 24-hour mean systolic blood pressure, 24-hour mean diastolic blood pressure and IgG and CD8+ levels, and positively correlated with CD4+ and CD4+/CD8+ levels (P<.05). The IL-17 level was positively correlated with 24-hour mean systolic blood pressure and 24-hour mean diastolic blood pressure in essential hypertension patients (P<.05). The levels of IgG and CD8+ were positively correlated, but negatively correlated with the levels of CD4+, CD4+ and CD8+ (P<.05).

Conclusion: The level of IL-10 in patients with essential hypertension is significantly lower than that in healthy subjects, and the level of IL-17 is significantly higher than that in healthy subjects. The above indexes are correlated with blood pressure and immune function.

Keywords

Essential hypertension, IL-10, IL-17, blood pressure, immune level, correlation.

DOI:

10.19193/0393-6384_2020_3_221