Authors

Jianjun Lan*, Lin Wang**, Shihai Wang*, Mengnian Ran*, Xiaobing Zeng1, Dawen Xu*, #

Departments

*Department of Cardiology, Central Hospital of Panzhihua City, Panzhihua, PR China - **The Third People's Hospital of Panzhihua City, Panzhihua, PR China

Abstract

Objective: The objective is to explore the correlation between the serum levels of angiopoietin-2 (Ang-2), galactose agglutinin-3 (Gal-3), B-type natriuretic peptide (BNP), and cardiac function in patients with chronic heart failure (CHF).

Methods: From January 2012 to June 2014, 135 patients with CHF were treated in the cardiovascular medicine department of our hospital and were selected as the observation group, and 45 normal persons were selected as the control group. According to the cardiac function classification of the New York Heart Association (NYHA), the patients with CHF in the observation group were divided into 42 cases of Grade I-II, 47 cases of Grade III, and 46 cases of Grade IV. Serum Ang-2, Gal-3, and BNP levels were measured in the observation and control groups along with their respective cardiac functions (left ventricular end-diastolic diameter (LVEDD), left atrial diameter (LAD), and left ventricular ejection fraction (LVEF). The correlations between serum Ang-2, Gal-3, and BNP levels and cardiac function in patients with CHF were analysed.

Results: The serum levels of Ang-2, Gal-3, and BNP in the observation group were significantly higher than those in the control group (P<0.05). The levels of LVEDD and LAD in the observation group were significantly higher than those in the control group, and the levels of LVEF in the observation group were significantly lower than those in the control group (P<0.05). With the increase of cardiac function grade, the serum Ang-2, Gal-3, and BNP levels in the observation group increased significantly, and the difference has statistical significance (P<0.05). The Pearson correlation analysis showed that serum levels of Ang-2, Gal-3, and BNP were positively correlated with the levels of LVEDD and LAD, and negatively correlated with the levels of LVEF. The receiver operator characteristic (ROC) curve analysis was established. The results showed that the areas under the curve (AUCs) of serum Ang-2, Gal-3, and BNP were 0.732, 0.836, and 0.833, respectively. The above indicators are valuable for the diagnosis of CHF.

Conclusion: Serum Ang-2, Gal-3, and BNP levels in patients with CHF are significantly higher than those in normal subjects and have a significant correlation with cardiac function.

Keywords

Chronic heart failure, Ang-2, Gal-3, BNP, cardiac function.

DOI:

10.19193/0393-6384_2020_3_250