Authors

Yang Zhang*, Lei Shi**, #, Yanmei Hu***, Ruifang Xue****, Ye Zhu*****

Departments

*Department of Geriatrics, Zhangye Second People's Hospital, Zhangye, PR China - **Department of Geriatrics, Jiuquan City People's Hospital, Jiuquan, PR China - ***Department of General Surgery, Zhangye Second People's Hospital, Zhangye, PR China - ****Department of Internal Medicine, Dongdong Township Hospital, Jiuquan, PR China - *****Department of Cardiology, West China Hospital, Sichuan University, Chengdu, PR China

Abstract

Objective: This article explored the correlation between ambulatory blood pressure monitoring parameters with urinary microalbumin/creatinine ratio (UACR), β2-microglobulin (β2-MG) and 25-hydroxyvitamin D3 [25(OH)D3]. 

Method: 49 patients with essential hypertension who were treated in our hospital from May 2017 to December 2018 were randomly selected as the study group. 50 healthy subjects who were examined at the same time in our hospital were selected as the control group. The inflammatory factor index (c-reactive protein, tumor necrosis factor-α, interleukin-18), ambulatory blood pressure monitoring parameters (average daytime systolic blood pressure, average daytime diastolic blood pressure, nighttime mean systolic blood pressure, night mean diastolic blood pressure, 24h average diastolic blood pressure, 24h average systolic blood pressure), UACR, β2-MG and 25(OH)D3 levels in each group were observed. The correlation between ambulatory blood pressure monitoring parameters and UACR, β2-MG and 25(OH)D3 in hypertensive patients was analyzed. 

Results: Compared with the control group, the levels of CRP, TNF-α and IL-18 in the study group were significantly increased (P<0.05). The DSBP, DDBP, NSBP, NDBP, 24hDBP and 24hSBP in the study group were significantly higher than the control group (P<0.05). Compared with the control group, the levels of UACR and β2-MG in the study group were significantly increased, and the levels of 25(OH)D3 were significantly decreased, and the differences were statistically significant (P<0.05). According to the Spearson correlation test, the results showed that the arterial blood pressure parameters were positively correlated with UACR, urinary β2-MG, CRP, TNF-α and TNF-α, and negatively correlated with 25(OH)D3 (P<0.05). 

Conclusion: The levels of inflammatory factors, UACR and urinary β2-MG in patients with hypertension are significantly higher than healthy subjects. The level of 25(OH)D3 is significantly lower than healthy people, and its level is significantly correlated with the dynamic blood pressure parameters of hypertensive patients.

Keywords

Hypertension, ambulatory blood pressure monitoring parameters, UACR, β2-MG, 25(OH)D3, correlation.

DOI:

10.19193/0393-6384_2020_3_275