Authors

Chunbo Fan, Jing Wang, Yanan He, Daojun Xi, Qingsong Lei, Deqing Liu, Jianfeng Li, Mao Sun, Cong Li, Qishuai Guo, Ying Wang#

Departments

Chongqing University Cancer Hospital, Chongqing

Abstract

Objective: To compare the dose distribution of tomography and intensity-modulated radiotherapy in the middle and lower thoracic oesophageal carcinoma on the heart and the change of myocardial zymography before and after tomography, and to explore the protective effect of tomography on cardiac function for the treatment of oesophageal cancer. 

Methods: Thirty seven patients with middle and lower thoracic oesophageal squamous carcinoma admitted to our hospital from August 2016 to December 2018 were selected and a plan was prepared for intensity-modulated radiotherapy and tomography to compare the PTV and heart dosimetry parameters of two radiotherapy methods. At the same time, myocardial zymography was examined at one week before and after tomotherapy, and the change of myocardial zymography in radiotherapy was compared. 

Results: The maximum dose of PTV and heart in tomography was significantly lower than that in intensity-modulated radiotherapy, the difference being significant (P<0.05). The heart V20~V60 of tomotherapy was significantly lower than that of intensity-modulated radiotherapy, the difference also being significant (P<0.05). The index of the two radiotherapy methods (0.80±0.06, 0.75±0.08) was significantly different (P<0.05), the homogeneity index saw no significant difference and the change in myocardial zymographys displayed no significant difference before and after radiotherapy. 

Conclusion: The conformity, homogeneity of dose distribution and dose distribution of the heart in the tomography are clearly superior to those of the intensity-modulated radiotherapy, and the early myocardial injury caused by tomography is not obvious, which has a certain protective effect on the heart.

Keywords

Tomography, thoracic oesophageal carcinoma, intensity-modulated radiotherapy, metrological comparison, myocardial zymography.

DOI:

10.19193/0393-6384_2020_3_334