Yong He#, Bohuai Xu, Lujie Yu, Bin Zhang


Department of Otorhinolaryngology, The Affiliated Hospital of Medical School of Ningbo University, Ningbo, 315020


Objectives: Allergic rhinitis (AR) is a common chronic disease, causing serious public health and medical problems. Single nucleotide polymorphisms (SNPs) in Surfactant protein A (SP-A) genes have recently been associated with allergic disorders. This study investigated the association of SP-A polymorphisms with the efficacy of AR allergen-specific immunotherapy (SIT). The results will provide guidance for targeted early prevention of AR and personalised SIT.

Methods: Nine SNPs of SP-A1 and SP-A2 were genotyped in 119 AR patients under SIT, using PCR sequence-specific-primers (PCR-SSP) method. Genotyping was validated by DNA sequence.

Results: We found that the SP-A1 50C/G GG genotype and the SP-A2 223A/C AC genotype are different in effective and ineffective groups. The other seven polymorphisms have no remarkable effects from SIT. Clinical characteristics, including gender, age, diagnostics, aggravating season, duration of illness, treatment history, surgery history, utopia, family history, house environment, dermatophagoides pteronyssinus, and dermatophagoides farina, had no significant correlation with the efficacy of SIT.

Conclusion: Our study indicates that the SP-A1/SP-A2 gene polymorphisms may correlate with the efficacy of SIT for the treatment of patients with AR.


Allergic rhinitis (AR), surfactant protein A (SP-A), allergen-specific immunotherapy (SIT), Single nucleotide polymorphisms (SNPs).