Authors

Jinbo Zong*, Caiping Chen**, Qinghua Zhu**, Bihong Liao***, #

Departments

*Cardiovascular medicine department, Yiwu Central Hospital, Yiwu, PR China - **Department of Cardiology, Yiwu Central Hospital, Yiwu, PR China - ***Department of Cardiology, Shenzhen People's Hospital, Second Clinical Medical College of Jinan University, Shenzhen, PR China

Abstract

Objective: To explore the correlation between ambulatory blood pressure parameters and serum creatine kinase, hypersensitive C-reactive protein, and cystatin C in patients with essential hypertension. 

Methods: A total of 102 patients with essential hypertension treated in our hospital from May 2017 to April 2018 were retrospectively analysed as an observation group, and 50 healthy adults were selected from the same period for a control group. Patients in the observation group and the control group were monitored by ambulatory blood pressure monitor 24 hours a day on the day of admission and physical examination. Hypersensitive C-reactive protein (hs-CRP) and cystatin C (CysC) were detected by latex-enhanced immunoturbidimetry, automatic biochemical analyser, and the COD-CE-PAP, GPO-PAP, and CEH/CHOD methods, respectively. Creatine kinase (CK), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) levels, as well as 24-hour mean systolic pressure (24hMSBP), 24-hour mean diastolic pressure (24hMDBP), and 24-hour mean arterial pressure (24hMABP), were compared between the two groups. The correlation between arterial blood pressure parameters (24hMSBP, 24hMDBP, 24hMDBP) and the levels of CK, hs-CRP, and CysC was analysed. 

Results: The levels of 24-hour MSBP, 24-hour MDBP, and 24-hour MABP were significantly higher in the observation group than in the control group (P<0.05). The levels of CK, hs-CRP, and CysC were significantly higher in the observation group than in the control group (P<0.05). The TC, TG, and LDL-C levels were significantly higher in the observation group than in the control group, while HDL-C levels were lower in the observation group than in the control group (P<0.05). Pearson correlation analysis revealed that 24h MABP is positively correlated with 24h MDBP, 24h MABP, CK, hs-CRP, and CysC (P<0.05). 

Conclusion: 24-hour MABP is positively correlated with 24-hour MDBP, 24-hour MABP, CK, hs-CRP, and CysC in patients with essential hypertension. Serum CK, hs-CRP, and CysC may be risk factors of high blood pressure in patients with essential hypertension and participate in the occurrence and development of hypertension, which has important value for early diagnosis of hypertension. 

Keywords

Essential hypertension, ambulatory blood pressure parameters, creatine kinase, hypersensitive C-reactive protein, cystatin C, correlation.

DOI:

10.19193/0393-6384_2020_3_323