Authors

Lichao Ye*, #, Yu Ting Huang**

Departments

*Department of Neurology, Second Affiliated Hospital of Fujian Medical University, Quanzhou, PR China - **Department of Clinical Laboratory, Second Affiliated Hospital of Fujian Medical University, Quanzhou, PR China

Abstract

Objective: We sought to analyse the clinical characteristics and significance of autonomic neuropathy in prediabetic patients. 

Methods: A total of 62 patients with impaired glucose regulation (IGR) and peripheral neuropathy (IGR group) and 60 normal controls were selected. The clinical features and risk factors of autonomic neuropathy in the IGR group were analysed and sympathetic skin response (SSR), heart rate changes during deep breathing, and supine–orthostatic blood pressure changes were compared between the two groups. 

Results: Autonomic neuropathy in IGR primarily manifests as less sweat, a dry mouth, dry eyes, bloating, constipation, frequent urination, dysuria, palpitations, and orthostatic dizziness. When compared with the normal control group, the IGR group demonstrated on the parameters of less sweat, dry mouth, and constipation (P<0.05). Moreover, the triglyceride, total cholesterol, low-density lipoprotein cholesterol, glycated haemoglobin, and uric acid serum levels were higher in the IGR group than among controls. A multivariate logistic regression analysis showed that elevated serum triglycerides, total cholesterol, and low-density lipoprotein cholesterol were risk factors for IGR autonomic neuropathy. Further, SSR and heart rate changes during deep breathing were significantly different (P<0.05), while supine-orthostatic blood pressure changes were not significantly different between the two groups (P>0.05). 

Conclusion: Autonomic neuropathy exists in IGR patients while presenting diverse manifestations, such as less sweat, dry mouth, and constipation. Elevated triglyceride, total cholesterol, and low-density lipoprotein cholesterol levels in serum were risk factors for IGR autonomic neuropathy. Additionally, SSR and altered heart rate during deep breathing can be used as indicators for the detection of prediabetic autonomic neuropathy.

Keywords

Impaired glucose regulation, diabetes, peripheral neuropathy, autonomic nerve, sympathetic skin response.

DOI:

10.19193/0393-6384_2020_3_246