Authors

Zhenning Han#, Lanfang Cai, Jianhong Zhou, Chenwang Duan, Li Li

Departments

Department of Burn and Plastic Surgery, Tangshan Gongren Hospital, Tangshan, PR China

Abstract

Objective: To study the neurological regulation effects of GDNF on septic rats and its signaling pathway. 

Methods: 40 sepsis rat models were established successfully and divided into sepsis group (20 cases) and GDNF group (20 cases). 20 sham-operated rats were selected as healthy group. The GDNF group was treated with GDNF through the subarachnoid space, and the other two groups were given normal saline. The neurological function of the three groups was compared and ERK1/2, pERK1/2, Akt and pAkt were tested. 

Results: The number of electric shocks in the three groups increased from the healthy group, the GDNF group to the sepsis group (P<0.05) and the number of active avoidance shocks decreased (P<0.05). The learning latency and memory latency of the three groups were prolonged from the healthy group, the GDNF group to the sepsis group (P<0.05). There was no significant change in ERK1/2 and Akt expression in the three groups. The expression levels of pERK1/2 and pAkt in the three groups increased from the healthy group, the sepsis group to the GDNF group (P<0.05). Conclusion: GDNF can improve the neurological function of septic rats, and the activation of ERK1/2 and GFR-α signal transduction pathway may be the way to effect.  

Keywords

GDNF, ERK12, GFR-α, sepsis, neurological function.

DOI:

10.19193/0393-6384_2020_3_330