Authors

Yina Liu, Xiaohuan Dou#

Departments

Department of Geriatrics, Tangshan Gongren Hospital, Tangshan, PR China

Abstract

Objective: To study the effects of levetiracetam on the Glasgow Coma Score (GCS), the Barthel index score, the MoCA score, and thyroid hormone levels in elderly patients with epilepsy.

Methods: Seventy elderly epileptic patients treated in the Department of Neurology from February 2018 to April 2019 were randomly divided into an observation group (n=35) and a control group (n=35). For 180 days, the control group was treated with carbamazepine tablets combined with phenobarbital tablets, and the observation group was treated with levetiracetam. The clinical efficacy on the two groups was compared, and changes in the GCS score, the Barthel index score, the MoCA score, and thyroid hormone levels before and after treatment were compared.

Results: After treatment, the total effective rate was 82.86% in the observation group and 60.00% in the control group. The total effective rate for the observation group was significantly higher than that of the control group (P<0.05). Before treatment, there was no significant difference in the GCS scores, the Barthel index scores, and the MoCA scores between the two groups. After treatment, the GCS scores, the Barthel index scores, and the MoCA scores for all participants were higher than before treatment. Moreover, and the scores for the observation group were significantly higher than those of the control group (P<0.05). Before treatment, there was no significant difference in thyroid hormone levels between the two groups (P>0.05). After treatment, the levels of T4, T3, and FT4 in the observation group were significantly lower than those in the control group (P<0.05). The incidence of adverse reactions was 8.57% in the observation group and 14.29% in the control group. There was no significant difference between the two groups in such things as gender, age, and type of disease (P>0.05).

Conclusion: Levetiracetam can improve functions for daily living, increase cognitive function, and reduce the depth of coma for elderly epileptic patients. This drug has obvious clinical curative effects, but it also raises certain concerns about safety. Nevertheless, its use in clinics can be promoted.

Keywords

Levetiracetam, elderly epilepsy, GCS score, barthel index score, MoCA score, thyroid hormone.

DOI:

10.19193/0393-6384_2020_3_230