Yan Yan*, Jing Sun**,  Shihui Sun***, Shenghai Cui**, #


*Department of Stomatology, Yantaishan Hospital, Yantai, PR China - **Department of Oral and Maxillofacial Surgery, Yantai Stomatological Hospital, Yantai, PR China - ***Department of Endodontics, Yantai Stomatological Hospital, Yantai, PR China


Objective: To investigate the expression of SALL4 in patients with oral squamous cell carcinoma (OSCC) and its correlation with clinicopathological features and prognosis. 

Methods: From September 2017 to June 2018, 52 patients with OSCC and 52 normal paracancerous tissues were randomly selected. The specimens of both groups were treated with 4% neutral formaldehyde and embedded in paraffin. The expression of human Borneo double tree-like gene 4 (SALL4) protein in OSCC and paracancerous tissues of oral squamous cell carcinoma was detected by immunohistochemistry, and the correlation between its expression and clinicopathological features and prognosis was investigated. 

Results: The positive expression rate of SALL4 in OSCC was 63.46%, which was significantly higher than that in the control group (15.38%, P<0.05). The expression of SALL4 was correlated with lymph node metastasis and TNM stage (P<0.05). The expression level of SALL4 was not correlated with age, sex, tumour size or tissue differentiation (P>0.05). The average survival time of patients with positive expression of SALL4 (26.31±2.48 months) was significantly shorter than that of patients with negative expression of SALL4 (34.16±1.37 months) (P<0.05). Lymph node metastasis, TNM stage and SALL4 expression can be used as independent risk factors for the prognosis of OSCC patients. 

Conclusion: The expression of SALL4 in OSCC is higher than that in paracancerous tissues, and its expression is related to clinicopathological features with lymph node metastasis and TNM stage, which may be used as a reference index with good sensitivity and specificity. 


Oral squamous cell carcinoma, clinicopathological features, prognosis, correlation of SALL4.