Authors

Bingyu Nie, Tao Sun, Xin Jiang, Xiaopan Zou, Tong Chen, Minghua Li, Jingbin Zhang#

Departments

Department of Breast Thyroid Surgery, Jilin Provincial People’s Hospital, Changchun, PR China

Abstract

Objective: To investigate the expression of peroxisome proliferator-activated agonist receptor gamma (PPARγ) and nuclear factor-kappa B (NF-κB) in patients with papillary thyroid carcinoma (PTC) and their correlation with tumor lymph node metastases and pathological stages.

Methods: The cancer tissues and nodular goiter tissues collected from 88 PTC patients, who were diagnosed in our hospital from January 2013 to December 2017, were assigned to study and control groups. The expression levels of PPARγ and NF-κB in the cancer tissues and nodular goiter tissues were detected using an immunohistochemical staining method, and their correlation with the pathological features of PTC was analyzed.

Results: The positive expression rates of PPARγ were 67% (59/88) and 32% (28/88) in the PTC tissues and nodular goiter tissues, respectively, and those of NF-κB were 85% (75/88) and 27% (24/88) in the PTC tissues and nodular goiter tissues, respectively, and the differences were statistically significant (P<0.05). There was a significant difference in the expression level of PPARγ in the cancer tissues of PTC patients with various pathological stages and lymph metastases (P<0.05). The expression level of PPARγ was significantly different in the PTC patients with various pathological stages, tumor infiltration degrees and lymph node metastases (P<0.05). The expressions of PPARγ and NF-κB were positively correlated in the PTC patients (P<0.05).

Conclusions: The expression levels of PPARγ and NF-κB see a rising trend in patients with PTC. The expression level of PPARγ is correlated with the pathological stages and lymph node metastases of the PTC patients, and the expression level of NF-κB is correlated with pathological stages, tumor infiltration degree and lymph node metastases of the PTC patients. The expressions of PPARγ and NF-κB are positively correlated in the PTC patients. 

Keywords

Papillary thyroid carcinoma, PPARγ, NF-κB, lymph node metastasis, pathological staging.

DOI:

10.19193/0393-6384_2020_3_270