Authors

Rong Sun1, Hefei Gao**, #, Xiaoyan Wang*, Hong Guan*, Yanli Hu*, Jiantao Meng*

Departments

*Department of Emergency, Xi'an Gaoxin Hospital, Xi’an, PR China - **Department of Respiratory Medicine, Xi'an Gaoxin Hospital, Xi’an, PR China

Abstract

Objective: The present paper discussed the early identification reference value of end-expiratory carbon dioxide partial pressure (PetCO2) in acute exacerbation of chronic obstructive pulmonary disease (AECOPD). 

Methods: A total of 60 patients with AECOPD treated in our emergency department from June 2018 to June 2019 were selected as the experimental group. They were divided into an acute stage and a stable stage according to the course of the disease. Overall, 30 healthy people who were examined at the physical examination center of our hospital during the same period were selected as the control group. Their pulmonary function, PetCO2, and PaCO2 levels were measured and compared to explore the early identification significance of PetCO2 in AECOPD.

Results: The levels of PaCO2 and ADCO2 in acute and stable stage groups were significantly higher than those of the control group (P<0.05). PaCO2 and ADCO2 in the acute phase group were significantly higher than those of the stable phase group (P<0.05). The level of PetCO2 in the acute stage group was significantly lower than that of both the stable stage and control groups (P<0.05). Moreover, the levels of FEV1, FEV1/FEV, and MMEF in the acute and stable stage groups were significantly lower than those in the control group, while the levels of sRAW and RV/TLC were significantly higher than those in the control group (P<0.05). The levels of FEV1, FEV1/FEV, and MMEF in the acute phase group were significantly lower than those of the control group, while the levels of sRAW and RV/TLC were significantly higher than those of the control group (P<0.05). PetCO2 was negatively correlated with PaCO2 in patients experiencing the acute stage (r=-0.663, p=0.006). It was positively correlated with FEV1, MMEF, sRAW, and RV/TLC (P<0.05). 

Conclusion: PetCO2 is negatively correlated with PaCO2, which can reflect changes in patients' conditions. Notably, paying close attention to PetCO2 has certain early recognition value for AECOPD.

Keywords

End-expiratory carbon dioxide partial pressure, chronic obstructive pulmonary disease, acute exacerbation, early recognition.

DOI:

10.19193/0393-6384_2020_3_220