Authors

Zuodong Lin, Dehai Lang#, Di Wang, Songjie Hu, Jie Sun

Departments

Department of Vascular Surgery, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, PR China

Abstract

Objective: This article explores the correlation of serum human matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) with carotid stenosis, plaque score and carotid intima-media thickness in patients with cerebral infarction. 

Method: 100 patients with cerebral infarction in our department of neurology from May 2018 to May 2019 were randomly selected as the study group. 30 healthy people in the physical examination centre of our hospital were selected as the control group. According to the degree of carotid stenosis, the patients were divided into three subgroups: no stenosis, mild to moderate stenosis and severe stenosis. According to plaque score, the patients were divided into subgroups 0–3. Carotid intima-media thickness (IMT) can be divided into three subgroups: plaque-forming, IMT-thickening, and normal IMT. The differences in MMP-9 and TIMP-1 levels between the groups were compared. 

Results: The level of MMP-9 in the study group was higher than that in the control group, and the difference was statistically significant (P<0.05). The TIMP-1 level in the study group was lower than that in the control group (P<0.05). The MMP-9 level in the normal IMT group was lower than that in the IMT-thickening group and the plaque-forming group. The MMP-9 level in the IMT-thickening group was lower than that in the plaque-forming group (P<0.05). The TIMP-1 level in the normal IMT group was higher than the IMT-thickening group and the plaque-forming group. The TIMP-1 level in the IMT-thickening group was higher than the plaque-forming group (P<0.05). The serum MMP-9 levels of patients were 0 group, 1 group, 2 group, 3 groups from low to high, and the difference was statistically significant (P<0.05). The serum MMP-9 level of patients ranged from low to high in groups 0, 1, 2 and 3 (P<0.05). The MMP-9 level in the patients without stenosis was lower than that in the mild to moderate stenosis group and the severe stenosis group. The MMP-9 level in the mild to moderate stenosis group was lower than that in the severe stenosis group (P < 0.05). The TIMP-1 level was higher in the patients without stenosis than in the mild to moderate stenosis group and the severe stenosis group. The TIMP-1 level in the mild to moderate stenosis group was higher than that in the severe stenosis group (P<0.05). Spearman correlation analysis showed that the serum MMP-9 level in patients with cerebral infarction was directly proportional to the degree of carotid stenosis (r = 00.785, P<0.05), which was proportional to plaque integral (r = 0.664, P<0.05) and the thickness of carotid intima-media (r = 0.698, P<0.05). The level of serum TIMP-1 in patients with cerebral infarction was inversely proportional to the degree of carotid stenosis (r = -0.751, P < 0.05) and the block integral (r = -0.759, P<0.05), which was inversely proportional to the carotid intima-media thickness (r = -0.648, P<0.05). 

Discussion: Serum MMP-9 and TIMP-1 are associated with carotid stenosis, plaque score and carotid intima-media thickness in patients with cerebral infarction. The clinical condition can be monitored by detecting MMP-9 and TIMP-1 levels.

Keywords

Cerebral infarction, MMP-9, TIMP-1, degree of carotid stenosis, plaque score, carotid intima-media thickness.

DOI:

10.19193/0393-6384_2020_3_241