Authors

Wenyue Chen*, Danfeng Shao*, Sufang Sun*, Xiaoping Yang**, #

Departments

*Department of Obstetrics and Gynecology, The first people’s Hospital of Fuyang District, Hangzhou, PR China - **Department of Obstetrics and Gynecology, Hangzhou Fuyang Hospital of Traditional Chinese Medicine, Hangzhou, PR China

Abstract

Objective: To explore the correlation between the expression of ABCG2 in cervical cancer tissues and the clinicopathological parameters and prognosis of patients with cervical cancer. 

Methods: The selected specimens were taken from paraffin specimens of gynaecological inpatients at our hospital from January 2015 to June 2016. They include 78 cervical cancer specimens and 20 normal cervical specimens. The expression of adenosine triphosphate binding cassette transporter G2 (ABCG2) in both cervical cancer and normal tissues was detected using immunohistochemistry. Further analysis was carried out regarding the correlation between the expression of ABCG2, and the clinicopathological parameters and prognosis of cervical cancer.

Results: The positive expression rate of ABCG2 was 62.82% (49/78) in cervical cancer tissues and 6.90% (1/20) in normal cervical tissues, demonstrating a significant difference in the positive expression rate of ABCG2 between the two groups (P<0.05). The expression of ABCG2 correlates with FIGO staging, tissue differentiation and lymph node metastasis in cervical cancer patients (P<0.05), but not with age, or the diameter of the tumour (P>0.05). The 5-year survival rate of patients with positive expression of ABCG2 was 32.65% (16/49). Patients with a negative expression of ABCG2 had a 58.62% (17/29) survival rate within the same period, demonstrating a significant difference between the two groups (P<0.05). The COX proportional risk regression model showed that differentiation, lymph node metastasis, FIGO staging and ABCG2 protein expression were independent risk factors affecting the prognosis of cervical cancer patients. 

Conclusion: The high expression of ABCG2 is closely related to the occurrence and development of cervical cancer. The expression level of ABCG2 is related to FIGO staging, tissue differentiation and lymph node metastasis in cervical cancer patients. Independent risk factors affecting the prognosis of cervical cancer patients include the degree of differentiation, lymph node metastasis, FIGO staging and ABCG2 protein expression. ABCG2 can be used as a molecular marker to predict the prognosis of cervical cancer.

Keywords

Cervical cancer, ABCG2, clinicopathological parameters, prognosis, correlation.

DOI:

10.19193/0393-6384_2020_3_231