Authors

Limei Ai*, Ge Zhang**, Shaoxin Yao*, #

Departments

*Department of Intervention, Tangshan Gongren Hospital, Tangshan, PR China - **Department of Geriatrics, Tangshan Gongren Hospital, Tangshan, PR China

Abstract

Objective: To investigate the correlation between serum stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor 4 (CXCR4) levels and clinical parameters in patients with type 2 diabetes mellitus and osteoarthritis.

Methods: Sixty-five (65) patients with type 2 diabetes mellitus and osteoarthritis (study group) who were treated in our hospital from June 2016 to August 2018 were recruited as the study group, and 65 healthy subjects who underwent a physical examination in our hospital were selected as the control group. The levels of fasting blood glucose (FBS) and glycated hemoglobin (HbAlc) in each group were determined using the glucose oxidase–peroxidase method. The insulin resistance index level was calculated according to FBS and FINS. The insulin resistance index = FBS × FINS/22.5. Changes in blood lipid levels [serum total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), and low density lipoprotein (LDL)] were measured using an automated biochemical analyzer. Serum levels of SDF-1 and CXCR4 were determined using an enzyme-linked immunosorbent assay. The correlation between serum SDF-1/CXCR4 levels and clinical indicators in patients with type 2 diabetes and osteoarthritis was analyzed according to the Pearson correlation test.

Results: Compared with the control group, the FBS, HbAlc, and insulin resistance index of the study group were significantly increased, and the Ca2+ level was significantly decreased (P<0.05). The levels of TC, TG, and LDL in the study group were significantly higher than those in the control group. The HDL level in the study group was significantly lower than that in the control group (P<0.05). Compared with the control group, the levels of SDF-1 and CXCR4 in the study group were significantly increased, and the differences were statistically significant (P<0.05). The Pearson correlation test showed that the levels of SDF-1/CXCR4 were positively correlated with insulin resistance index, HbAlc, TC, TG, and LDL levels, and negatively correlated with Ca2+ and HDL levels (P<0.05).

Conclusion: The levels of HbAlc, insulin resistance index, TC, TG, LDL, SDF-1, and CXCR4 in patients with type 2 diabetes and osteoarthritis are significantly higher than those in normal subjects. The levels of Ca2+ and HDL are significantly lower than those of normal subjects. The level of SDF-1/CXCR4 is positively correlated with HbAlc, insulin resistance index, TC, TG, and LDL, but negatively correlated with Ca2+ and HDL levels. SDF-1/CXCR4 may be involved in the development of type 2 diabetes and osteoarthritis, and may become the target for future treatment of this disease, and has achieved the best efficacy. 

Keywords

Type 2 diabetes, osteoarthritis, SDF-1/CXCR4, clinical indexes, correlation.

DOI:

10.19193/0393-6384_2020_3_225