Authors

Hui Zhang*, Zhaojian Cao**, #, JianBo Huang***

Departments

*Department of Cardiology Resident, Yiwu Central Hospital, Yiwu, PR China - **Department of Cardiovascular Medicine, People's Hospital of Qijiang District, Chongqing, PR China - ***Department of Cardiology of Beijing Road, General Hospital of Xinjiang Military Region, Urumqi, PR China

Abstract

Objective: The objective is to analyse the correlation between serum complement C3, C4, and C5b-9 levels and the Gensini score in patients with acute myocardial infarction.

Methods: Eighty patients with acute myocardial infarction in our hospital from November 2016 to September 2018 were randomly selected for the study group, and 80 healthy subjects who underwent a physical examination in this hospital were selected for the control group. Serum complement C3 and C4 levels were determined by nephelometry. Serum complement C5b-9, serum adiponectin (APN), and C-reactive protein (CRP) levels were measured by enzyme-linked immunosorbent assay. The Pearson correlation test was used to analyse the correlation between serum complement C3, C4, and C5b-9 levels and the Gensini score in patients with acute myocardial infarction.

Results: Serum complement C3, C4, and C5b-9 levels in the study group were significantly higher compared with those of the control group, and these indicators obviously increased with the increase in the Gensini score (P<0.01). The CRP and Gensini scores in the study group were markedly higher than those in the control group, while serum APN levels were significantly lower than those in the control group (P<0.01). With the increase in the Gensini score, the serum APN level significantly decreased, and the CRP level was significantly elevated (P<0.01). Serum complement C3, C4, C5b-9, CRP, and APN levels were correlated with the Gensini score according to the Pearson correlation test, and these indicators were positively correlated with the Gensini score, while APN levels were negatively correlated with the Gensini score (P<0.05).

Conclusion: Serum CRP, C3, C4, and C5b-9 levels in patients with acute myocardial infarction are significantly higher than those in healthy subjects. Serum APN levels are significantly lower than those in healthy subjects. The Pearson correlation test analysis showed that the above indicators were significantly correlated with the Gensini score, which can be used as an effective indicator to reflect the degree of coronary artery disease in patients with acute myocardial infarction. 

Keywords

Acute myocardial infarction, complement C3, complement C4, complement C5b-9, Gensini score, correlation.

DOI:

10.19193/0393-6384_2020_3_318