Authors

Guoqiang Wang, Jianbo Hu, Xueqin Huang, Xuejun Yu#

Departments

Department of Cardiology, Chongqing Kanghua Zhonglian Cardiovascular Hospital, Chongqing, PR China

Abstract

Objective: To explore the changes of Tp-e, Tp-e/QT, and Tp-ed in patients with variant angina pectoris (VAP), and to explore the value of Tp-e, Tp-e/QT, and Tp-ed in predicting malignant arrhythmia (MVAE).

Method: 68 patients with VAP treated in our hospital from July 2018 to July 2019 were divided into a study group (n=28) and a control group (n=40) based on whether they had malignant arrhythmia or not. The differences in Tp-e, Tp-e/QT, and the Tp-ed ratio between the two groups were measured and compared. The relationship between Tp-e, Tp-e/QT, Tp-ed and malignant arrhythmia was analysed by binary logistic single-factor and multi-factor analysis, and a ROC curve was used to analyse the value of Tp-e, Tp-e/QT, and Tp-ed for predicting malignant arrhythmic events.

Result: The Tp-e, Tp-e/QT, and Tp-ed values of the study group were higher than those of the control group, and the difference was statistically significant (P < .01). Univariate binary logistic analysis showed that Tp-e (OR = 1.082; 95% CI = 1.034-1.129; P<.01), Tp-e/QT (OR = 1.015; 95% CI = 1.006-1.028; P<.01), and Tp-ed (OR = 1.113; 95% CI = 1.048-1.172; P<.01) were related to MVA; multivariate binary logistic analysis showed that only three parameters of Tp-ed/QT could enter the regression equation, and OR and CI did not change compared with single-factor analysis. When Tp-ed/QT was removed from the model, only Tp-ed entered the equation, and OR and CI remained unchanged. When Tp-ed/QT ratio and Tp-ed were removed from the model, only Tp-e entered the equation, and OR and CI remained unchanged. The ROC curve analysis showed that the AUC of Tp-e was 0.845, and the best diagnostic node was 112.00ms. The sensitivity and specificity were 82.56% and 80.59%, respectively. The AUC of Tp-e/QT was 0.752, and the best diagnostic node was 0.28. The sensitivity and specificity were 74.21% and 78.49%, respectively. The AUC of Tp-ed was 0.892, and the best diagnostic node was 42.52ms. The sensitivity and specificity were 86.89% and 82.14%, respectively.

Conclusion: The values of Tp-e, Tp-e/QT, and Tp-ed all increased in patients with VAP at onset, and they are valuable for predicting MVAE events.

Keywords

Tp-e, Tp-e/QT, Tp-ed, variant angina pectoris, malignant arrhythmia.

DOI:

10.19193/0393-6384_2020_3_253