Authors

Naizhong Wang*,#, Hong Wu*, Jinjun Li*, Guan Jiang**

Departments

*Department of Dermatology, Huai'an Dermatology Hospital, Huai An, 223200, China - **Department of Dermatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, China

Abstract

tiligo is the most common cause of acquired skin, hair and mouth discoloration, affecting 0.5-1% of the world's population. Although biologists explore all aspects of the pathogenesis and treatment of vitiligo, the molecular mechanisms of vitiligo remain elusive. This experiment conducted a modular study on the pathogenesis and treatment mechanism of vitiligo, and finally explored its effective therapeutic drugs to achieve the goal of reducing its harm to the human nervous system. First, differential expression analysis (DEG) was performed based on vitiligo and normal sample genes and mapped to protein-protein interaction networks (PPIs). Secondly, a modular analysis of this vitiligo-related PPIs identified 20 functional modules. Subsequently, we conducted a Crosstalk analysis between modules and found that there are interactive control relationships between functional modules. The module gene was subjected to enrichment analysis of GO function and KEGG pathway, and it was found that the module gene was significantly involved in Nrf2-ARE, Mitf promoter, methylation, Wnt, melanin and other related signaling pathways. Then, based on the important role of non-coding RNA (ncRNA) and transcription factors in transcriptional and post-transcriptional regulation, we identified ncRNA pivot (including miR-590-3p, miR-340-5p, etc.) and TF pivot (including E2F1, TBX1, etc.) significantly regulates dysfunction modules. Finally, drug and drug targets were predicted for the vitiligo dysfunction module, and it was found that Bleomycin drugs have a significant regulatory effect on the module. These drugs may be effective drugs for the treatment of vitiligo. In general, we have revealed how transcription factors, ncRNA-related genes regulate the development and progression of vitiligo, and potential drugs provide important research value for drug researchers. These findings provide a valuable reference for the development of vitiligo drugs and the design of personalized treatments.

Keywords

Vitiligo, protein interaction network, module, transcription factor, signaling pathway.

DOI:

10.19193/0393-6384_2020_3_282