Xiaohui Liu*, Xiaoying Zhang**, Wenxiu Liu***, Yuqin Bai****, Haibing Ding****, Chang Su*,#


*Department of Pathology, Medical College of Chifeng University, Chifeng P.RChina 024000 - **Department of Pathology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, P.R.China 300250 - ***Department of Internal Medicine-Cardiovascular, Bethune International Peace Hospital, P.R.China 050081 - ****Department of Pathophysiology, Medical College of Chifeng University, Chifeng P.R.China 024000 - *****Department of thoracic surgery, Taizhou Second People's Hospital, Jiangsu, P.R.China 225500


Objective: To analyze the features of the clinical data, including the onset age, tissue type, microscopic findings and onset site in 142 central type carcinoma of lung patients diagnosed by the biopsy of fiber bronchoscope, and to compare the roles of bronchial brushing and perfusion in diagnosis of central type carcinoma of lung.

Methods: Patients who were diagnosed as the central type carcinoma of lung through the biopsy of fiber bronchoscope between January 2016 and December 2018 were enrolled into this study to analyze the features of age, microscopic finding, pathological type and lesions, and compare the positive rate in bronchial brushing and perfusion. 

Results: Among all patients, 39.43% of them aged between 60 and 69 years old, 31.68% between 50 and 59 years old, 19.01% between 40 and 49 years old and 9.87% between 70 and 79 years old. For pathological type, 50.57% of patients had squamous carcinoma, 22.54% had small cell anaplastic carcinoma, 16.20% had adenocarcinoma and 10.56% had other types. According to the microscopic findings, proliferative changes were found in 75 patients (52.82%), infiltration in 57 patients (40.14%) and both of them in 7 patients (4.93%) and hollow in 3 patients (2.11%). Among the patients with the positive responses to the perfusion and bronchial brushing examinations, squamous carcinoma was detected in the largest proportion of all patients; among these adenocarcinoma patients with positive response to the bronchial brushing, lesion were usually detected in the left upper lobe and right lower lung; for those with squamous carcinoma, lesions were mainly found in the left upper lobe, right lower lung and middle bronchus, with a positive rate of about 30%, and in right principal bronchus of 2 patients, with a positive rate of 100%. As for the small cell anaplastic carcinoma, the highest positive rate was also identified in the brushing test of the central airway, followed by the left lung. For adenocarcinoma patients with positive responses to the brushing test, the right lower lobe was the mostly affected organ, while for squamous carcinoma, right upper lobe and central bronchus were the major affected organs, and for the small cell anaplastic carcinoma patients, their left upper lobe was mainly affected.

Conclusion: Features of the clinical data, including onset age, tissue type, microscopic findings and affected sites, of the central type carcinoma of lung patients in this hospital are similar to those as reported in other Chinese literatures. As a result, fiber bronchoscopy is the major pathway for the observation and acquirement of the target tissues that are necessary for the pathological test, and brushing test and perfusion are of great significance for identification of the carcinoma type and site. Thus, in clinical practice, these methods are worthy of being promoted. 


Central type carcinoma of lung, fiber bronchoscope, biopsy.