LP-PLA2, HBA1C AND HS-CRP IN PATIENTS WITH ISCHEMIC STROKE AND ITS CORRELATION WITH END

WEI RONG*, YONG YAN*, AIMEI WANG*, JUN HU*, LINZHU WU*, ZHAODE ZHOU*, LI YANG**

*Department of Neurology; the Second Affiliated Hospital of Kunming Medical University, No. 374, Yunnan Burma Road, Kunming, 650101 - **Kunming Medical University, No. 1168, spring melts West Road, Yuhua street, Chenggong, Kunming, 650500

Introduction: To investigate lipoprotein-associated phospholipase A2 (Lp-PLA2), glycosylated hemoglobin (HbA1c) and hypersensitive-C- reactive protein in patients with acute ischemic stroke (AIS) (hypersensitive C reaction protein, hs-CRP) expression changes and correlation with early neurologic deterioration (END).

Methods: A total of 396 patients with AIS in our department of cardiology or ICU from August 2015 to July 2017 were enrolled, and These patients were divided into END group (n=99) and non-END group (n=297). The expressions of Lp-PLA2, HbA1c and hs-CRP in peripheral blood were compared between the two groups, and the correlation between Lp-PLA2, HbA1c, hs-CRP and END was explored.

Results: Lp-PLA2, HbA1c and hs-CRP in the END group were significantly higher than those in the non-END group (p<0.05). In addition, the NIHSS score of the END group was (7.65±2.62), which was higher than that of the non-END group (p<0.05). The more severe the END degree, the higher the peripheral blood Lp-PLA2, HbA1c, and hs-CRP levels (p<0.05). Multivariate logistic regression analysis showed that the risk of END in AIS patients was positively correlated with the expression of Lp-PLA2, HbA1c, and hs-CRP (p<0.05).

Conclusion: The expression of Lp-PLA2, HbA1c and hs-CRP in peripheral blood in acute ischemic stroke was increased, and it was closely related to the early deterioration of neurological function.