YAN XU, FENG WU, HUIZHEN DING#
Department of Respiratory, the Affiliated Hospital of Yangzhou University
Objectives: The focus of this study was to investigate the influence of soluble myeloid cell trigger receptor-1, procalcitonin, and C-reactive protein on lower respiratory tract bacterial infection in patients with chronic obstructive pulmonary disease (COPD).
Methods: Sixty patients with acute exacerbation of COPD admitted to our hospital from April 2017 to March 2018 were selected. Twenty- six patients with bacterial infection comprised the infected group, and 34 patients without bacterial infection comprised the non-infected group. Another 40 patients with acute exacerbation of COPD who were stable after treatment comprised the stable group, and 35 healthy subjects were used as the healthy control group. White blood cell count (WBC), soluble myeloid cell trigger receptor-1 (sTREM-1), C-reactive protein (CRP), and procalcitonin (PCT) levels in the fasting serum of each group were measured by enzyme-linked immunosorbent assay.
Results: The fasting serum PCT, sTREM-1, and CRP levels in the infected group were significantly higher than those in the non-infected, stable, and healthy control groups (P<0.05). There was no significant difference in fasting serum PCT, sTREM-1, and CRP between the stable group and the non-infected and healthy control groups after treatment (P>0.05). There was no significant difference in serum WBC levels between the four groups (P>0.05). Serum sTREM-1 and PCT levels in the extremely severe group were significantly higher than those in the mild-to-moderate group (P<0.01); there was no significant difference in CRP levels between the groups (P>0.05).
Conclusion: Serum sTREM-1 and PCT influence lower respiratory tract bacterial infection in patients with acute exacerbation of COPD.
sTREM-1, PCT, COPD, bacterial infections.
10.19193/0393-6384_2019_5_378