EFFECTS OF XUEBIJING COMBINED WITH ANTIBIOTICS ON TH CELL SUBGROUP, OXYGENATION INDEX AND SEROLOGICAL INDEXES IN PATIENTS WITH AN ABDOMINAL INFECTION

YING GUO*, RUILIAN MA1, LINLIN PAN2, JIALI GAO1,*

1Department of Pharmacy, Affiliated Hospital of Inner Mongolia Medical University, No. 1 Tongdao North Road, Huimin District, Hohhot City, Inner Mongolia, 010050, China - 2Department of Trauma Orthopedics, The Second Affiliated Hospital of Inner Mongolia Medical University, No. 1 Yingfang Road, Huimin District, Hohhot City, Inner Mongolia, 010030, China

Objective: To investigate the effect of a combination of xuebijing and antibiotics on Th cell subgroup, oxygenation index (OI) and serological indexes in patients with an abdominal infection.

Methods: There were 56 patients with severe abdominal infection admitted and diagnosed in our hospital from December 2015 to December 2017 who were randomly divided into the control group (ceftriaxone sodium) and the study group (xuebijing injection combined with antibiotics), with 28 cases each. The clinical efficacy, adverse reactions and oxygenation index of the two groups were observed by tracking changes to vital signs including systolic blood pressure (SBP), body temperature, respiratory rate, diastolic blood pressure (DBP) and heart rate. The changes of blood routine and blood biochemical indexes in the two groups were observed, including haemoglobin (Hb), leukocytes (WBC), platelets (PLT), procalcitonin (PCT), C-reactive protein (CRP) and lactic acid (LA). The levels of Th cell subsets (CD3+, CD4+, CD4+/CD8+) in the two groups were also observed.

Results: The total effective rate in the study group (92.86%) was significantly higher than the results in the control group (67.86%), and the difference was statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). After treatment, heart rate, respiratory rate, body temperature, SBP, CD3+ value, CD4+ value, CD4+/CD8+ value, OI, WBC, CRP, PCT, LA, Hb, PLT in the two groups were statistically significant (P<0.05). After treatment, the values of CD3+, CD4+, CD4+/CD8+ and OI in the study group were significantly higher than those in the control group (P<0.05). After treatment, heart rate, body temperature, WBC, CRP and PCT of the study group were significantly lower than those of the control group (P<0.05).

Conclusion: A combination of xuebijing and antibiotics to treat an intraperitoneal infection can safely improve the oxygenation index, immune levels, and serological index of patients.