CD10 IS A GOOD BIOMARKER TO PREDICT BACTERIAL INFECTION IN SEPSIS-SUSPECTED PATIENTS

JIE LIU*, HANG SHI**, JIAN YU***, JUNYU XIONG*,#

*Department of anesthesiology, The second affiliated hospital of Dalian medical university, Dalian, Liaoning116027, China - **Department of dermatology, the first affiliated hospital of Dalian medical university, Dalian, Liaoning116021, China - ***Department of ICU, the second affiliated hospital of Dalian medical university, Dalian, Liaoning 116027, China

Objective: This study first examined if CD10 expression can be used as a biomarker to predict bacterial infection in the suspected sepsis. Then, the correlation between CD10 expression and the severity of sepsis.

Methods: The blood samples from 168 suspected septic patients were collected for CRP, PCT and CD66b+CD10- expression. The results were statistically evaluated with the scores of SOFA, APACHE II, and MODS.

Results: The prediction accuracy of CD10 expression for bacterial infection was much higher than that of CRP and PCT. However, the AUC of CD66b+CD10-, CRP and PCT were too low to predict the 28-day mortality in septic patients. SOFA, APACHE II, and MODS showed no correlation with the expression of CD66b+CD10- in the peripheral blood of the suspect septic patients.

Conclusion: Peripheral blood CD66b+CD10- is an effective biomarker for the prediction of early bacterial infection, but invalid for death prediction and no correlation with the severity of sepsis.