School of Chemical and Biological Engineering, Hechi University, Hechi, 546300, China
Chalcone, a polyphenolic compound that belongs to flavonoids family, has revealed a variety of biological activities that may benefit human health such as anti-tumor cell growth. This natural compound is mainly found in the composition of Chinese herbal medicine such as safflower. Drug splicing method has been known to enhance the chalcone’s activities. Thus in this paper, the reac- tion between ketoacetic acid and enoic acid, in the presence of silver nitrate catalyst and water, was employed for the derivation of chalcone compounds. The derived compounds have inhibitory effect on protein aggregation as well as anti-inflammatory and anti- bacterial activity. This method which yields 89% of final product is a new green and environmental-friendly technique for the synthe- sis of chalcone compounds.
chalcone compounds, drug splicing principle, modified synthesis