Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250014, China


Objective: This paper aims to observe and analyze the effect of addition and subtraction ofGuipi decoction on blood pressure and the quality of life for hypertension elderly patients complicated with depression.

Methods: Total of 120 elderly patients diagnosed with hypertension and depression were selected as the study subjects. According to different treatment regimens, the patients were randomly divided into two groups. The analysis of clinical trials involves observation and comparison between patients with addition and subtraction of Guipi Decoction (referred as study group) and refe- rence group that received western drug therapy.

Results: The scores of 17 Hamilton Depression Scale (HAMD17), Health Status Questionnaire (SF-36), Hamilton Anxiety Scale (HAMA) and Treatment Drug Side Effects Scale (TESS) were measured to evaluate therapeutic effect of the two groups. The results showed that the indicators of study group were significantly better than the reference group (P <0.05). At the same time, chan- ges of blood pressure before and after treatment were not significantly different between both the groups (P> 0.05). Nevertheless after treatment, study group showed more significant advantages (P> 0.05).

Conclusion: Application of addition and subtraction of Guipi decoction for the elderly patients with hypertension complicated with depression can give full play to curative effect, significantly improve the patients’ blood pressure levels, while improving their quality of life by alleviating depression symptoms, so it is worthy of promotion in treatment.


elderly hypertension with depression, addition and subtractation Guipi decoction, blood pressure improvement,quality of life