IS TIGECYCLINE EFFECTIVE IN CONTINUOUS AMBULATORY PERITONEAL DIALYSIS RELATED PERITONITIS

AYŞE SAĞMAK TARTAR¹, MEHMET ÖZDEN², AYHAN DOĞUKAN³, AYHAN AKBULUT⁴, KUTBEDDIN DEMIRDAĞ⁵, TUGAY TARTAR⁶

¹Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Firat University, Elaziğ,Turkey - ²Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, İnönü University, Malatya, Turkey - ³Department of Nephrology, Faculty of Medicine, Firat University, Elaziğ, Turkey - ⁴Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Firat University, Elaziğ, Turkey - ⁵Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Firat University, Elaziğ, Turkey - ⁶Department of Pediatric Surgery, Firat University, Faculty of Medicine, Elaziğ, Turkey

Introduction: To compare conventional intraperitoneal vancomycin-amikacin and intravenous tigecycline treatments for continuous ambulatory peritoneal dialysis (CAPD) related peritonitis.

Materials and methods: Patients diagnosed with CAPD-related peritonitis were randomized into two groups as intravenous tigecycline group (n=10) and intraperitoneal vancomycinamikacin group (n=20). Patients accompanied by peritonitis exit site infection, peritonitis based on Pseudomonas or fungi were excluded from the study.

Results: As for 24th and 48th hours peritoneal fluid leukocyte count of patients, significant difference was not observed in tigecycline group at 24th hours, while significant reduction was observed in vancomycinamikacin group (p<0.05). A significant reduction was observed at 48th hours in both groups. As for the treatment response, abdominal pain decreased in 18 (90%) patients in vancomycinamikacin group, decreased in 8 (80%) patients in tigecycline group at 48th hours. It was detected that dialysate leukocyte count decreased significantly (p>0.05). Relapse was observed in 4 (40%) patients in tigecycline group, while not observed in vancomycinamikacin group (p<0.05).

Conclusion: Tigecycline proved its effectiveness in the clinical use for complicated intra-abdominal infections. However, it was considered that tigecycline cannot be alternative to vancomycinamikacin treatment for continuous ambulatory peritoneal dialysis related peritonitis.