MUSTAFA EROĞLU*, FARUK OZKUL**, GOKHAN ERBAG***, AHMET TEMIZ****, BURAK ALTUN****, KASIM ARIK**, HACER SEN**, EMINE
BINNETOGLU**, MEHMET ASIK*
*Çanakkale Onsekiz Mart University, Faculty of Medicine, Department of Endocrinology and Metabolism, Canakkale - *Çanakkale Onsekiz Mart University, Faculty of Medicine, Department of General Surgery, Canakkale, Turkey - ***Çanakkale Onsekiz Mart University, Faculty of Medicine, Department of General Medicine, Çanakkale, Turkey - ****Çanakkale Onsekiz Mart University, Faculty of Medicine, Department of Cardiology, Canakale, Turkey
Introduction: It has been shown that epicardial fat tissue (EFT) thickness in primary hyperparathyroidism (PHPT) is increased and that this is closely associated with cardiovascular disease and atherosclerosis. However, EFT thickness in patients with hyperpa- rathyroidism who were treated with parathyroidectomy has not yet been studied. In this study we aimed to examine whether carotid intima-media thickness (CIMT) and EFT thickness would be affected after treatment of PHPT by parathyroidectomy.
Materials and methods: 27 patients with PHPT who were diagnosed with a parathyroidectomy indication and 39 healthy volun- teers were included in the study. For all patients with PHPT, anthropometric measurements were made before and 12 months after parathyroidectomy, and EFT thickness, CIMT, serum parathormone (PTH), calcium and lipid levels were measured.
Results: It was observed that preoperative CIMT and EFT thickness in patients with PHPT were significantly higher than the control group (for both p< 0.001). Although hyperparathyroidism and hypercalcemia of the patients improved after parathyroidec- tomy, no significant change in the thickness of CIMT or EFT was determined.
Conclusions: CIMT and EFT thickness seem to be good cardiovascular indicators for diagnosis of patients with PHPT. Nevertheless, this study raises the question of the reliability of a decrease in these parameters in patient follow-up. It is therefore necessary to be more careful in evaluating these parameters after treatment of patients with PHPT.
epicardial fat tissue (EFT), carotid intima-media thickness (CIMT)