BING LIU*,**, XUN DING***, JIONG YANG*,**
*Department of Respiratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, China -
**The Second Clinical Medicine College of Wuhan University, Wuhan, Hubei, 430071, China -
***Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, China
Introduction: Heart failure (HF) is one of the major condition able to determine bilateral pleural effusion. The diagnostic value of combined use of Brain natriuretic peptide (BNP) and Light’s criteria in the diagnosis of HF is unclear.
Materials and methods: 109 patients with both heart failure and bilateral pleural were included in this study. Serum BNP, pleural effusion character were analyzed. The diagnostic sensitivity and specificity of BNP and Light’s criteria in the diagnosis of HF were analyzed.
Results: 109 patients were included. Serum BNP and percentage of Light’s negative patients are higher in patients with HF than those without. When combining BNP positive with Light’s criteria together, the diagnostic sensitivity increased to 86.8%. BNP negative together with Light’s positive had a good exclusive diagnostic value. The cutoff value of BNP was proved to be 186.9 pg/ml the diagnosis of HF for patients with bilateral pleural effusion.
Conclusion: Combined use of BNP and Light’s criteria could increase the diagnostic sensitivity in patients with bilateral pleural effusion and could help recognize those without HF. For patients with bilateral pleural effusion, serum BNP test should be the initial test to recognize and differentially diagnose HF.
BNP, Light’s Criteria, heart failure, bilateral pleural effusion.